Relationship between gut microbiota and nutritional status in patients on peritoneal dialysis. (bibtex)
by Na Tian, Yinyin Yan, Na Chen, Siyao Xu, Rui Chu, Mengting Wang, Surong Duan, Hongyan Ren, Shuhua Song, Li Wang, Xiaoqin Ma, Mei Xu, Li Na, Menghua Chen and Philip Kam-Tao Li
Abstract:
Malnutrition is a common complication in the dialysis population, both hemodialysis and peritoneal dialysis (PD). We report our exploratory study on the characteristics of intestinal microbiota and nutritional status in PD patients. The nutritional status of our PD patients were evaluated, and their feces were collected for 16S rRNA gene V3-V4 regions amplification and high-throughput sequencing. The characteristics and differences of microbiota between the well-nourished (W) and malnourished (M) groups were compared. We studied the genera and the operational taxonomic units (OTUs) within the genus of our patients, initially comparing the malnourished and the well- nourished groups and later on reanalyzing the whole group using these OTUs. At the OTU level, 6 bacteria were significantly correlated with the serum albumin level. The abundances of 2 OTUs (OTU208 Lachnospiraceae_incertae_sedi and OTU4 Bacteroides) were more in W group. Meanwhile, 4 OTUs (OTU225 Akkermansia, OTU87 Megasphaera, OTU31 Peptostreptococcaceae_incertae_sedi and OTU168 Clostridium_sensu_strictu) displayed higher abundance among individuals in M group. Notably, the OTU168 Clostridium_sensu_stricto was the only bacteria that significantly correlated with serum albumin (r = - 0.356, P = 0.05), pre-albumin (r = - 0.399, P = 0.02), and SGA (r = 0.458, P = 0.01). The higher the OTU168 Clostridium_sensu_strictu, the lower serum albumin and pre-albumin and a higher score of SGA signifying a worse nutritional status. Our preliminary findings suggested a relationship between the nutrition status and microbiota in PD patients. Our results provide a basis for further exploration of the interactions between malnutrition and intestinal flora in PD patients with potential interventions using probiotics and prebiotics.
Reference:
Relationship between gut microbiota and nutritional status in patients on peritoneal dialysis. (Na Tian, Yinyin Yan, Na Chen, Siyao Xu, Rui Chu, Mengting Wang, Surong Duan, Hongyan Ren, Shuhua Song, Li Wang, Xiaoqin Ma, Mei Xu, Li Na, Menghua Chen and Philip Kam-Tao Li), In Sci Rep, volume 13, 2023.
Bibtex Entry:
@article{Tian:2023aa,
	abstract = {Malnutrition is a common complication in the dialysis population, both hemodialysis and peritoneal dialysis (PD). We report our exploratory study on the characteristics of intestinal microbiota and nutritional status in PD patients. The nutritional status of our PD patients were evaluated, and their feces were collected for 16S rRNA gene V3-V4 regions amplification and high-throughput sequencing. The characteristics and differences of microbiota between the well-nourished (W) and malnourished (M) groups were compared. We studied the genera and the operational taxonomic units (OTUs) within the genus of our patients, initially comparing the malnourished and the well- nourished groups and later on reanalyzing the whole group using these OTUs. At the OTU level, 6 bacteria were significantly correlated with the serum albumin level. The abundances of 2 OTUs (OTU208 Lachnospiraceae_incertae_sedi and OTU4 Bacteroides) were more in W group. Meanwhile, 4 OTUs (OTU225 Akkermansia, OTU87 Megasphaera, OTU31 Peptostreptococcaceae_incertae_sedi and OTU168 Clostridium_sensu_strictu) displayed higher abundance among individuals in M group. Notably, the OTU168 Clostridium_sensu_stricto was the only bacteria that significantly correlated with serum albumin (r = - 0.356, P = 0.05), pre-albumin (r = - 0.399, P = 0.02), and SGA (r = 0.458, P = 0.01). The higher the OTU168 Clostridium_sensu_strictu, the lower serum albumin and pre-albumin and a higher score of SGA signifying a worse nutritional status. Our preliminary findings suggested a relationship between the nutrition status and microbiota in PD patients. Our results provide a basis for further exploration of the interactions between malnutrition and intestinal flora in PD patients with potential interventions using probiotics and prebiotics.},
	address = {Department of Nephrology, General Hospital of Ningxia Medical University, No.804 Shengli Road, Yinchuan, 750004, Ningxia, China. tianna@nxmu.edu.cn.; Department of Nephrology, General Hospital of Ningxia Medical University, No.804 Shengli Road, Yinchuan, 750004, Ningxia, China.; Department of Nephrology, General Hospital of Ningxia Medical University, No.804 Shengli Road, Yinchuan, 750004, Ningxia, China.; Department of Respiratory Medicine, Hanzhong Central Hospital, Shanxi, 723000, China.; Department of Nephrology, General Hospital of Ningxia Medical University, No.804 Shengli Road, Yinchuan, 750004, Ningxia, China.; Department of Nephrology, General Hospital of Ningxia Medical University, No.804 Shengli Road, Yinchuan, 750004, Ningxia, China.; Department of Nephrology, General Hospital of Ningxia Medical University, No.804 Shengli Road, Yinchuan, 750004, Ningxia, China.; Shanghai Mobio Biomedical Technology Co. Ltd., Shanghai, 201100, China.; Department of Nephrology, General Hospital of Ningxia Medical University, No.804 Shengli Road, Yinchuan, 750004, Ningxia, China.; Department of Nephrology, General Hospital of Ningxia Medical University, No.804 Shengli Road, Yinchuan, 750004, Ningxia, China.; Department of Nephrology, General Hospital of Ningxia Medical University, No.804 Shengli Road, Yinchuan, 750004, Ningxia, China.; Department of Nephrology, General Hospital of Ningxia Medical University, No.804 Shengli Road, Yinchuan, 750004, Ningxia, China.; BioBank of General Hospital of Ningxia Medical University, Ningxia, 750004, China.; Department of Nephrology, General Hospital of Ningxia Medical University, No.804 Shengli Road, Yinchuan, 750004, Ningxia, China. nxchenmh@163.com.; Department of Medicine and Therapeutics, Carol and Richard Yu Peritoneal Dialysis Research Centre, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong, China. philipli@cuhk.edu.hk.},
	auid = {ORCID: 0000-0002-0284-5897},
	author = {Tian, Na and Yan, Yinyin and Chen, Na and Xu, Siyao and Chu, Rui and Wang, Mengting and Duan, Surong and Ren, Hongyan and Song, Shuhua and Wang, Li and Ma, Xiaoqin and Xu, Mei and Na, Li and Chen, Menghua and Li, Philip Kam-Tao},
	cois = {The authors declare no competing interests.},
	copyright = {{\copyright}2023. The Author(s).},
	crdt = {2023/01/28 23:54},
	date = {2023 Jan 28},
	date-added = {2023-05-24 17:19:39 +0100},
	date-modified = {2023-05-24 17:20:19 +0100},
	dcom = {20230131},
	dep = {20230128},
	doi = {10.1038/s41598-023-27919-3},
	edat = {2023/01/29 06:00},
	issn = {2045-2322 (Electronic); 2045-2322 (Linking)},
	jid = {101563288},
	journal = {Sci Rep},
	jt = {Scientific reports},
	keywords = {Peritoneal Dialysis},
	language = {eng},
	lid = {10.1038/s41598-023-27919-3 {$[$}doi{$]$}; 1572},
	lr = {20230314},
	mh = {Humans; Nutritional Status; *Gastrointestinal Microbiome/genetics; RNA, Ribosomal, 16S/genetics; Renal Dialysis; *Peritoneal Dialysis/adverse effects; *Malnutrition; Bacteria/genetics; Clostridium/genetics; Serum Albumin},
	mhda = {2023/02/01 06:00},
	month = {Jan},
	number = {1},
	own = {NLM},
	pages = {1572},
	phst = {2022/08/26 00:00 {$[$}received{$]$}; 2023/01/10 00:00 {$[$}accepted{$]$}; 2023/01/29 06:00 {$[$}pubmed{$]$}; 2023/02/01 06:00 {$[$}medline{$]$}; 2023/01/28 23:54 {$[$}entrez{$]$}},
	pii = {10.1038/s41598-023-27919-3; 27919},
	pl = {England},
	pmc = {PMC9884196},
	pmid = {36709367},
	pst = {epublish},
	pt = {Journal Article; Research Support, Non-U.S. Gov't},
	rn = {0 (RNA, Ribosomal, 16S); 0 (Serum Albumin)},
	sb = {IM},
	status = {MEDLINE},
	title = {Relationship between gut microbiota and nutritional status in patients on peritoneal dialysis.},
	url = {https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9884196/pdf/41598_2023_Article_27919.pdf},
	volume = {13},
	year = {2023},
	bdsk-url-1 = {https://doi.org/10.1038/s41598-023-27919-3}}
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