by María Victoria Pendón-Ruiz De Mier, Noemí Vergara, Cristian Rodelo-Haad, María Dolores López-Zamorano, Cristina Membrives-González, Rodrigo López-Baltanás, Juan Rafael Muñoz-Castañeda, Francisco Caravaca, Alejandro Martín-Malo, Arnold J. Felsenfeld, Eugenio J. De La Torre, Sagrario Soriano, Rafael Santamaría and Mariano Rodríguez
Abstract:
In chronic kidney disease (CKD) patients, it would be desirable to reduce the intake of inorganic phosphate (P) rather than limit the intake of P contained in proteins. Urinary excretion of P should reflect intestinal absorption of P(inorganic plus protein-derived). The aim of the present study is to determine whether the ratio of urinary P to urinary urea nitrogen (P/UUN ratio) helps identify patients with a high intake of inorganic P.A cross-sectional study was performed in 71 patients affected by metabolic syndrome with CKD (stages 2–3) with normal serum P concentration. A 3-day dietary survey was performed to estimate the average daily amount and the source of P ingested. The daily intake of P was 1086.5 $\pm$ 361.3 mg/day; 64% contained in animal proteins, 22% in vegetable proteins, and 14% as inorganic P. The total amount of P ingested did not correlate with daily phosphaturia, but it did correlate with the P/UUN ratio (p \textless 0.018). Patients with the highest tertile of the P/UUN ratio \textgreater71.1 mg/g presented more abundant inorganic P intake (p \textless 0.038).The P/UUN ratio is suggested to be a marker of inorganic P intake. This finding might be useful in clinical practices to identify the source of dietary P and to make personalized dietary recommendations directed to reduce inorganic P intake.
Reference:
Assessment of Inorganic Phosphate Intake by the Measurement of the Phosphate/Urea Nitrogen Ratio in Urine (María Victoria Pendón-Ruiz De Mier, Noemí Vergara, Cristian Rodelo-Haad, María Dolores López-Zamorano, Cristina Membrives-González, Rodrigo López-Baltanás, Juan Rafael Muñoz-Castañeda, Francisco Caravaca, Alejandro Martín-Malo, Arnold J. Felsenfeld, Eugenio J. De La Torre, Sagrario Soriano, Rafael Santamaría and Mariano Rodríguez), In Nutrients, volume 13, 2021.
Bibtex Entry:
@article{pendon-ruiz_de_mier_assessment_2021,
abstract = {In chronic kidney disease (CKD) patients, it would be desirable to reduce the intake of inorganic phosphate (P) rather than limit the intake of P contained in proteins. Urinary excretion of P should reflect intestinal absorption of P(inorganic plus protein-derived). The aim of the present study is to determine whether the ratio of urinary P to urinary urea nitrogen (P/UUN ratio) helps identify patients with a high intake of inorganic P.A cross-sectional study was performed in 71 patients affected by metabolic syndrome with CKD (stages 2--3) with normal serum P concentration. A 3-day dietary survey was performed to estimate the average daily amount and the source of P ingested. The daily intake of P was 1086.5 $\pm$ 361.3 mg/day; 64\% contained in animal proteins, 22\% in vegetable proteins, and 14\% as inorganic P. The total amount of P ingested did not correlate with daily phosphaturia, but it did correlate with the P/UUN ratio (p {\textless} 0.018). Patients with the highest tertile of the P/UUN ratio {\textgreater}71.1 mg/g presented more abundant inorganic P intake (p {\textless} 0.038).The P/UUN ratio is suggested to be a marker of inorganic P intake. This finding might be useful in clinical practices to identify the source of dietary P and to make personalized dietary recommendations directed to reduce inorganic P intake.},
author = {Pend{\'o}n-Ruiz De Mier, Mar{\'\i}a Victoria and Vergara, Noem{\'\i} and Rodelo-Haad, Cristian and L{\'o}pez-Zamorano, Mar{\'\i}a Dolores and Membrives-Gonz{\'a}lez, Cristina and L{\'o}pez-Baltan{\'a}s, Rodrigo and Mu{\~n}oz-Casta{\~n}eda, Juan Rafael and Caravaca, Francisco and Mart{\'\i}n-Malo, Alejandro and Felsenfeld, Arnold J. and De La Torre, Eugenio J. and Soriano, Sagrario and Santamar{\'\i}a, Rafael and Rodr{\'\i}guez, Mariano},
date-added = {2023-07-26 20:41:54 +0100},
date-modified = {2023-07-26 20:41:54 +0100},
doi = {10.3390/nu13020292},
issn = {2072-6643},
journal = {Nutrients},
keywords = {Phosphorus},
language = {en},
month = jan,
number = {2},
pages = {292},
title = {Assessment of {Inorganic} {Phosphate} {Intake} by the {Measurement} of the {Phosphate}/{Urea} {Nitrogen} {Ratio} in {Urine}},
url = {https://www.mdpi.com/2072-6643/13/2/292},
urldate = {2023-07-26},
volume = {13},
year = {2021},
bdsk-url-1 = {https://www.mdpi.com/2072-6643/13/2/292},
bdsk-url-2 = {https://doi.org/10.3390/nu13020292}}