Red meat consumption, cardiovascular diseases, and diabetes: a systematic review and meta-analysis (bibtex)
by Wenming Shi, Xin Huang, C Mary Schooling and Jie V Zhao
Abstract:
Abstract Aims Observational studies show inconsistent associations of red meat consumption with cardiovascular disease (CVD) and diabetes. Moreover, red meat consumption varies by sex and setting, however, whether the associations vary by sex and setting remains unclear. Methods and results This systematic review and meta-analysis was conducted to summarize the evidence concerning the associations of unprocessed and processed red meat consumption with CVD and its subtypes [coronary heart disease (CHD), stroke, and heart failure], type two diabetes mellitus (T2DM), and gestational diabetes mellitus (GDM) and to assess differences by sex and setting (western vs. eastern, categorized based on dietary pattern and geographic region). Two researchers independently screened studies from PubMed, Web of Science, Embase, and the Cochrane Library for observational studies and randomized controlled trials (RCTs) published by 30 June 2022. Forty-three observational studies (N = 4 462 810, 61.7% women) for CVD and 27 observational studies (N = 1 760 774, 64.4% women) for diabetes were included. Red meat consumption was positively associated with CVD [hazard ratio (HR) 1.11, 95% confidence interval (CI) 1.05 to 1.16 for unprocessed red meat (per 100 g/day increment); 1.26, 95% CI 1.18 to 1.35 for processed red meat (per 50 g/day increment)], CVD subtypes, T2DM, and GDM. The associations with stroke and T2DM were higher in western settings, with no difference by sex. Conclusion Unprocessed and processed red meat consumption are both associated with higher risk of CVD, CVD subtypes, and diabetes, with a stronger association in western settings but no sex difference. Better understanding of the mechanisms is needed to facilitate improving cardiometabolic and planetary health.
Reference:
Red meat consumption, cardiovascular diseases, and diabetes: a systematic review and meta-analysis (Wenming Shi, Xin Huang, C Mary Schooling and Jie V Zhao), In European Heart Journal, 2023.
Bibtex Entry:
@article{shi_red_2023,
	abstract = {Abstract 
             
              Aims 
              Observational studies show inconsistent associations of red meat consumption with cardiovascular disease (CVD) and diabetes. Moreover, red meat consumption varies by sex and setting, however, whether the associations vary by sex and setting remains unclear. 
             
             
              Methods and results 
              This systematic review and meta-analysis was conducted to summarize the evidence concerning the associations of unprocessed and processed red meat consumption with CVD and its subtypes [coronary heart disease (CHD), stroke, and heart failure], type two diabetes mellitus (T2DM), and gestational diabetes mellitus (GDM) and to assess differences by sex and setting (western vs. eastern, categorized based on dietary pattern and geographic region). Two researchers independently screened studies from PubMed, Web of Science, Embase, and the Cochrane Library for observational studies and randomized controlled trials (RCTs) published by 30 June 2022. Forty-three observational studies (N = 4 462 810, 61.7\% women) for CVD and 27 observational studies (N = 1 760 774, 64.4\% women) for diabetes were included. Red meat consumption was positively associated with CVD [hazard ratio (HR) 1.11, 95\% confidence interval (CI) 1.05 to 1.16 for unprocessed red meat (per 100 g/day increment); 1.26, 95\% CI 1.18 to 1.35 for processed red meat (per 50 g/day increment)], CVD subtypes, T2DM, and GDM. The associations with stroke and T2DM were higher in western settings, with no difference by sex. 
             
             
              Conclusion 
              Unprocessed and processed red meat consumption are both associated with higher risk of CVD, CVD subtypes, and diabetes, with a stronger association in western settings but no sex difference. Better understanding of the mechanisms is needed to facilitate improving cardiometabolic and planetary health.},
	author = {Shi, Wenming and Huang, Xin and Schooling, C Mary and Zhao, Jie V},
	date-added = {2023-07-21 07:42:48 +0100},
	date-modified = {2023-07-21 07:43:36 +0100},
	doi = {10.1093/eurheartj/ehad336},
	issn = {0195-668X, 1522-9645},
	journal = {European Heart Journal},
	keywords = {Red Meat},
	language = {en},
	month = jun,
	pages = {ehad336},
	shorttitle = {Red meat consumption, cardiovascular diseases, and diabetes},
	title = {Red meat consumption, cardiovascular diseases, and diabetes: a systematic review and meta-analysis},
	url = {https://academic.oup.com/eurheartj/advance-article/doi/10.1093/eurheartj/ehad336/7188739},
	urldate = {2023-07-17},
	year = {2023},
	bdsk-url-1 = {https://academic.oup.com/eurheartj/advance-article/doi/10.1093/eurheartj/ehad336/7188739},
	bdsk-url-2 = {https://doi.org/10.1093/eurheartj/ehad336}}
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