by Guobin Su, Valeria Saglimbene, Germaine Wong, Amélie Bernier-Jean, Juan Jesus Carrero, Patrizia Natale, Marinella Ruospo, Jorgen Hegbrant, Jonathan C. Craig and Giovanni F. M. Strippoli
Abstract:
Dietary phosphorus restrictions are usually recommended for people on haemodialysis, although its impact on patient-relevant outcomes is uncertain. We aimed to evaluate the association between total phosphorus intake and its sources with mortality in haemodialysis. Phosphorus intake was ascertained within the DIET-HD study in 8110 adults on haemodialysis. Adjusted Cox regression analyses were conducted to evaluate the association between the total and source-specific phosphorus (plant-, animal-, or processed and other sources) with mortality. During a median 3.8 years of follow-up, there were 2953 deaths, 1160 cardiovascular-related. The median phosphorus intake was 1388 mg/day. Every standard deviation (SD) (896 mg/day) increase in total phosphorus was associated with higher all-cause mortality [hazard ratio (HR), 1.16; 95% confidence intervals (CI), 1.06–1.26] and cardiovascular mortality (HR, 1.18; 95% CI, 1.03–1.36). Every SD (17%) increase in the proportion of phosphorus from plant sources was associated with lower all-cause mortality (HR, 0.95; 95% CI, 0.90–0.99). Every SD (9%) increase in the proportion of phosphorus from the processed and other sources was associated with higher all-cause mortality (HR, 1.06; 95% CI, 1.02–1.10). A higher total phosphorus intake was associated with increased all-cause and cardiovascular death. This association is driven largely by the phosphorus intake from processed food. Plant based phosphorus was associated with lower all-cause mortality.
Reference:
Dietary Phosphorus, Its Sources, and Mortality in Adults on Haemodialysis: The DIET-HD Study (Guobin Su, Valeria Saglimbene, Germaine Wong, Amélie Bernier-Jean, Juan Jesus Carrero, Patrizia Natale, Marinella Ruospo, Jorgen Hegbrant, Jonathan C. Craig and Giovanni F. M. Strippoli), In Nutrients, volume 14, 2022.
Bibtex Entry:
@article{su_dietary_2022,
abstract = {Dietary phosphorus restrictions are usually recommended for people on haemodialysis, although its impact on patient-relevant outcomes is uncertain. We aimed to evaluate the association between total phosphorus intake and its sources with mortality in haemodialysis. Phosphorus intake was ascertained within the DIET-HD study in 8110 adults on haemodialysis. Adjusted Cox regression analyses were conducted to evaluate the association between the total and source-specific phosphorus (plant-, animal-, or processed and other sources) with mortality. During a median 3.8 years of follow-up, there were 2953 deaths, 1160 cardiovascular-related. The median phosphorus intake was 1388 mg/day. Every standard deviation (SD) (896 mg/day) increase in total phosphorus was associated with higher all-cause mortality [hazard ratio (HR), 1.16; 95\% confidence intervals (CI), 1.06--1.26] and cardiovascular mortality (HR, 1.18; 95\% CI, 1.03--1.36). Every SD (17\%) increase in the proportion of phosphorus from plant sources was associated with lower all-cause mortality (HR, 0.95; 95\% CI, 0.90--0.99). Every SD (9\%) increase in the proportion of phosphorus from the processed and other sources was associated with higher all-cause mortality (HR, 1.06; 95\% CI, 1.02--1.10). A higher total phosphorus intake was associated with increased all-cause and cardiovascular death. This association is driven largely by the phosphorus intake from processed food. Plant based phosphorus was associated with lower all-cause mortality.},
author = {Su, Guobin and Saglimbene, Valeria and Wong, Germaine and Bernier-Jean, Am{\'e}lie and Carrero, Juan Jesus and Natale, Patrizia and Ruospo, Marinella and Hegbrant, Jorgen and Craig, Jonathan C. and Strippoli, Giovanni F. M.},
date-added = {2023-07-21 07:37:19 +0100},
date-modified = {2023-07-21 07:37:53 +0100},
doi = {10.3390/nu14194064},
issn = {2072-6643},
journal = {Nutrients},
keywords = {Phosphorus},
language = {en},
month = sep,
number = {19},
pages = {4064},
shorttitle = {Dietary {Phosphorus}, {Its} {Sources}, and {Mortality} in {Adults} on {Haemodialysis}},
title = {Dietary {Phosphorus}, {Its} {Sources}, and {Mortality} in {Adults} on {Haemodialysis}: {The} {DIET}-{HD} {Study}},
url = {https://www.mdpi.com/2072-6643/14/19/4064},
urldate = {2023-07-17},
volume = {14},
year = {2022},
bdsk-url-1 = {https://www.mdpi.com/2072-6643/14/19/4064},
bdsk-url-2 = {https://doi.org/10.3390/nu14194064}}