The Role of Vitamin K Status in Cardiovascular Health: Evidence from Observational and Clinical Studies (bibtex)
by A. J. van Ballegooijen and J. W. Beulens
Abstract:
PURPOSE OF REVIEW: Vitamin K is a fat-soluble vitamin required for the activation of several vitamin K-dependent proteins to confer functioning. A growing body of evidence supports that vitamin K has beneficial effects on bone and cardiovascular health. This review summarizes key evidence on vitamin K status as measured by circulating measures and cardiovascular outcomes. RECENT FINDINGS: Overall, observational studies indicate that low vitamin K status as measured by high dephosphorylated uncarboxylated matrix gla protein concentrations plays a potential role in cardiovascular disease development, particularly in high-risk and chronic kidney disease populations. Very few vitamin K intervention trials have been conducted with cardiovascular-related outcomes. A couple of intervention trials studied the effect of the combination of vitamin D + K supplementation, which might have synergistic effects compared to vitamin K supplementation alone. SUMMARY: Assessing vitamin K status in prospective studies and well-designed randomized trials would provide important insight whether vitamin K is causally related to vascular calcification and cardiovascular disease.
Reference:
The Role of Vitamin K Status in Cardiovascular Health: Evidence from Observational and Clinical Studies (A. J. van Ballegooijen and J. W. Beulens), In Current Nutrition Reports, volume 6, 2017.
Bibtex Entry:
@article{van_ballegooijen_role_2017,
	abstract = {PURPOSE OF REVIEW: Vitamin K is a fat-soluble vitamin required for the activation of several vitamin K-dependent proteins to confer functioning. A growing body of evidence supports that vitamin K has beneficial effects on bone and cardiovascular health. This review summarizes key evidence on vitamin K status as measured by circulating measures and cardiovascular outcomes.
RECENT FINDINGS: Overall, observational studies indicate that low vitamin K status as measured by high dephosphorylated uncarboxylated matrix gla protein concentrations plays a potential role in cardiovascular disease development, particularly in high-risk and chronic kidney disease populations. Very few vitamin K intervention trials have been conducted with cardiovascular-related outcomes. A couple of intervention trials studied the effect of the combination of vitamin D + K supplementation, which might have synergistic effects compared to vitamin K supplementation alone.
SUMMARY: Assessing vitamin K status in prospective studies and well-designed randomized trials would provide important insight whether vitamin K is causally related to vascular calcification and cardiovascular disease.},
	author = {van Ballegooijen, A. J. and Beulens, J. W.},
	date-added = {2023-07-21 18:27:53 +0100},
	date-modified = {2023-07-21 18:28:15 +0100},
	doi = {10.1007/s13668-017-0208-8},
	issn = {2161-3311},
	journal = {Current Nutrition Reports},
	keywords = {Vitamin K},
	language = {eng},
	number = {3},
	pages = {197--205},
	pmcid = {PMC5585988},
	pmid = {28944098},
	shorttitle = {The {Role} of {Vitamin} {K} {Status} in {Cardiovascular} {Health}},
	title = {The {Role} of {Vitamin} {K} {Status} in {Cardiovascular} {Health}: {Evidence} from {Observational} and {Clinical} {Studies}},
	volume = {6},
	year = {2017},
	bdsk-url-1 = {https://doi.org/10.1007/s13668-017-0208-8}}
Powered by Portal da Diálise