Mechanisms of heme iron absorption: current questions and controversies (bibtex)
by Adrian-R. West and Phillip-S. Oates
Abstract:
Iron is a critical micronutrient, and iron derived from heme contributes a large proportion of the total iron absorbed in a typical Western diet. Heme iron is absorbed by different mechanisms than non-heme iron, but despite considerable study over many years these mechanisms remain poorly understood. This review provides an overview of the importance of heme iron in the diet and discusses the two prevailing hypotheses of heme absorption; namely receptor mediated endocytosis of heme, and direct transport into the intestinal enterocyte by recently discovered heme transporters. A specific emphasis is placed on the questions surrounding the site of heme catabolism and the identity of the enzyme that performs this task. Additionally, we present the hypothesis that a non-heme iron transport protein may be required for heme iron absorption and discuss the experiences of our laboratory in examining this hypothesis.
Reference:
Mechanisms of heme iron absorption: current questions and controversies (Adrian-R. West and Phillip-S. Oates), In World Journal of Gastroenterology, volume 14, 2008.
Bibtex Entry:
@article{west_mechanisms_2008,
	abstract = {Iron is a critical micronutrient, and iron derived from heme contributes a large proportion of the total iron absorbed in a typical Western diet. Heme iron is absorbed by different mechanisms than non-heme iron, but despite considerable study over many years these mechanisms remain poorly understood. This review provides an overview of the importance of heme iron in the diet and discusses the two prevailing hypotheses of heme absorption; namely receptor mediated endocytosis of heme, and direct transport into the intestinal enterocyte by recently discovered heme transporters. A specific emphasis is placed on the questions surrounding the site of heme catabolism and the identity of the enzyme that performs this task. Additionally, we present the hypothesis that a non-heme iron transport protein may be required for heme iron absorption and discuss the experiences of our laboratory in examining this hypothesis.},
	author = {West, Adrian-R. and Oates, Phillip-S.},
	date-added = {2023-07-21 18:25:15 +0100},
	date-modified = {2023-07-21 18:26:17 +0100},
	doi = {10.3748/wjg.14.4101},
	issn = {1007-9327},
	journal = {World Journal of Gastroenterology},
	keywords = {Heme Iron},
	language = {eng},
	month = jul,
	number = {26},
	pages = {4101--4110},
	pmcid = {PMC2725368},
	pmid = {18636652},
	shorttitle = {Mechanisms of heme iron absorption},
	title = {Mechanisms of heme iron absorption: current questions and controversies},
	volume = {14},
	year = {2008},
	bdsk-url-1 = {https://doi.org/10.3748/wjg.14.4101}}
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